The soles of the feet have a lot of small blisters, itchy, consider the following possibilities: 1, eczema, mainly due to contact with rubber, or shoes made of plastic caused by an allergic reaction. In clinical practice, you can take oral loratadine citrate capsules, 1 capsule every night, combined with compound glycopyrrolate capsules, 3 times a day, 2 capsules a time. For small blisters, if they are the size of a pinpoint, they can be applied topically with Denide ointment 1:1 mixed with zinc oxide borate ointment. If the small blisters fuse into large blisters, you can use a sterile syringe to draw the blisters and then apply fusidic acid ointment for treatment. 2, consider the possibility of palmoplantar pustulosis is more likely, mainly a disease of unclear etiology, part of the doctrine confirmed that there is a relationship with wearing dentures and other factors, but the cause of this disease has not been completely determined. The actual fact is that you can take oral glycopyrrolate capsules and apply topical fluticasone propionate ointment for treatment.