Coughing out very yellow sticky sputum, most of which may be related to respiratory diseases, but also may be related to acute sinusitis and other diseases, need to be treated according to different causes. Cough with yellow sticky sputum, may be acute upper respiratory tract infection, acute bronchitis or lung infection and other conditions, can be actively anti-infective treatment, such as the use of amoxicillin, cefoperazone sulbactam sodium and other antibacterial drugs. Phlegm transforming drugs can take aminobromine hydrochloride, bromhexine and so on. Acute sinusitis, if the nasal cavity yellow pus is more, the pus will flow back to the mouth or throat, when coughing, there will be yellow mucus phlegm from the mouth, mistaken for coughing phlegm. Nasal drops of 1% ephedrine saline can be used, while penicillin antibiotics such as amoxicillin are given to actively fight infection. Coughing up phlegm that is very yellow and thick, you need to consult a doctor to clarify the cause, and follow the doctor’s instructions for standardized treatment. In the course of treatment, we should pay attention to a light diet, drink more water, pay attention to rest.