Proton pump inhibitors are drugs that inhibit the secretion of stomach acid. Proton pump inhibitors are a class of drugs currently used in the treatment of peptic ulcers, which are widely used in the treatment of gastritis, duodenal ulcers, gastric ulcers, Helicobacter pylori, and even reflux esophagitis by efficiently and rapidly inhibiting the secretion of gastric acid. The commonly used proton pump inhibitors in clinic include omeprazole enteric-coated capsules, lansoprazole enteric-coated tablets, pantoprazole sodium enteric-coated capsules and rabeprazole sodium enteric-coated capsules and other drugs. Clinically, depending on different indications or conditions, different drugs of the rabeprazole class can be chosen to control symptoms. Proton pump inhibitors are available in oral dosage form and injectable dosage form, and the adverse reactions are mainly manifested as nausea, flatulence, diarrhea, constipation, etc., which usually disappear automatically after stopping the drug. It is recommended to follow the doctor’s advice, and note that liver and kidney insufficiency, as well as pregnant women and children should not be used, and it is best to take it 30 minutes to 1 hour before meals. It is recommended to go to the hospital in time for early and regular treatment.