Large myocardial infarction should be quickly opened up blood vessels, given aspirin, clopidogrel, statin and other drugs, patients with heart failure should be given furosemide and other drugs. Large myocardial infarction has a high risk of sudden death and is prone to cardiogenic shock and heart failure. After the onset of the disease, it is necessary to scramble for rescue and open the blood vessels as soon as possible, which can be given to drug thrombolysis, and hospitals that have the conditions can carry out emergency PCI treatment to open the lesion quickly and reduce myocardial necrosis. At the same time, basic treatment should be given, such as aspirin, clopidogrel, atorvastatin, isosorbide nitrate and other drugs orally to inhibit platelets, stabilize plaque, dilate the coronary artery, and reduce myocardial necrosis. Some patients will have heart failure after infarction, which is manifested as the symptom of dyspnea. On the basis of basic treatment, drugs such as furosemide and hydrochlorothiazide can be added to reduce the cardiac load. Massive myocardial infarction is an internal medicine emergency, and after the onset of the disease, it is necessary to quickly go to the hospital for regular treatment to reduce the risk of sudden death and improve the prognosis and quality of life.