Earth kinase and clopidogrel differ in composition, indications, contraindications, etc., so it is not possible to say which drug is more effective, and should be used in accordance with medical advice. Earth kinase is an enzyme extracted from earthworms, with the effect of inhibiting platelet aggregation, clinically used in the treatment of ischemic cerebrovascular disease patients with increased fibrinogen or platelet aggregation rate. Adverse reactions such as dizziness and headache can occur after the use of the drug, and should not be used by people who are allergic to the product. Clopidogrel can inhibit platelet activation, thus inhibiting platelet aggregation, and can be used to prevent thrombosis in patients with acute coronary syndrome and recent myocardial infarction. Adverse reactions such as bleeding may occur after administration. This drug should not be used in patients with severe liver damage and active bleeding. All of the above drugs can inhibit platelet aggregation, but due to different indications, adverse reactions and other factors, a direct comparison cannot be made, and the appropriate drug should be selected for treatment according to the patient’s specific condition.