Toothache is related to a variety of diseases such as apical periodontitis, periodontitis, pulpitis, etc. Patients can take anti-inflammatory and pain-relieving medications such as metronidazole and ibuprofen as prescribed by the doctor according to their condition, and surgical treatment if necessary. 1. Apical periodontitis: generally do not choose drug treatment but serious bacterial infection, can be prescribed to take cefixime, penicillin and other antibiotic treatment, pain can take acetaminophen, ibuprofen and other non-steroidal anti-inflammatory drugs to relieve. In addition to medication, patients in the acute stage need open pulp drainage, incision and drainage of pus, as well as surgical treatments such as root canal therapy and tooth extraction. 2. Periodontitis: acute stage with periodontal abscess, need to cooperate with the doctor incision drainage treatment. Those with calculus need to be treated with supragingival scaling and subgingival scraping. If the condition of periodontitis is serious, it is necessary to cooperate with the doctor to carry out flap surgery, bone grafting, dental implantation and other surgical treatments. At the same time, you can follow the doctor’s instructions for local use of minocycline gel, chlorhexidine acetate solution and other antibiotic treatment, but also oral metronidazole, amoxicillin and other drugs. Acetaminophen, diclofenac sodium and other anti-inflammatory drugs can also be taken to relieve the symptoms of toothache. 3. Pulpitis: patients in the acute stage need to open the pulp drainage to reduce pain, and some patients can also be directly capped pulp surgery, pulpotomy, endodontics and apical induction molding, apical barrier surgery and other surgical treatments. At the same time, local injection of anesthetics such as procaine to achieve the purpose of pain relief, or take indomethacin, celecoxib and other non-steroidal anti-inflammatory drugs as prescribed by the doctor to relieve.