Diffuse glioma is one kind of glioma, and children suffering from this disease should be treated mainly by surgery, combined with radiotherapy, immunotherapy and so on. Diffuse glioma belongs to malignant tumor, and clinical treatment for this disease is mainly based on surgery. Therefore, when children are diagnosed with diffuse glioma, they can seek medical treatment by undergoing craniotomy, which can help reduce intracranial pressure, control the disease and relieve the discomfort caused by the disease. In addition to surgical treatment, post-surgical treatment can also be combined with radiation therapy, chemotherapy, photodynamic therapy, thermal therapy and other comprehensive treatments depending on the condition. If children with diffuse glioma have epilepsy, they can be treated with antiepileptic drugs such as sodium valproate and levetiracetam as prescribed by the doctor, and furosemide and mannitol can be used to alleviate the elevated intracranial pressure. It is recommended that children with diffuse glioma should actively cooperate with doctors, and should not use drugs indiscriminately on their own. Parents need to pay attention to children’s psychological care, more communication, if necessary, medical psychotherapy. Parents should also pay attention to children’s balanced intake of nutrients, regular medical review.