Liver cancer with intrahepatic metastasis can be treated with chemotherapy, radiotherapy, targeted drug therapy and liver transplantation. 1. Chemotherapy, at present, new type of liver cancer chemotherapy drug is oxaliplatin, and traditional chemotherapy drugs include fluorouracil, cisplatin and so on. 2. Radiotherapy, for liver cancer with intrahepatic metastasis, radiotherapy can be used. 3. Targeted drug therapy, such as sorafenib and lenvatinib, has good therapeutic effect. 4. Liver transplantation, for intrahepatic metastasis, liver transplantation can be chosen to improve the quality of patient’s survival. Liver cancer has already developed intrahepatic metastasis, most of them have lost the chance of radical surgical treatment, and they should also be actively treated, which can help prolong the survival period and improve the quality of patient’s survival. Drugs should be applied under doctor’s guidance.