Hepatitis B two-half core antibody positive may be infected with hepatitis B virus, or considered to have been infected with hepatitis B virus. Its clinical significance needs to be combined with the patient’s own situation, comprehensive judgment, can not be generalized. Hepatitis B five indicators include: the first item of hepatitis B virus surface antigen, the second item of hepatitis B virus surface antibody, the third item of hepatitis B virus e antigen, the fourth item of hepatitis B virus e antibody, the fifth item of hepatitis B virus core antibody. If the first, third and fifth items are positive, it can be called triple positive, which suggests that the hepatitis B virus is actively replicating and highly infectious. If the first, fourth and fifth items are positive, it can be called minor triple positive, compared with major triple positive, its virus replication is weaker and less infectious. If the second, fourth and fifth items are positive, it can indicate that the patient is cured or recovered, with certain immunity, and there is no contagiousness at this time. The second and fifth items are positive, which can indicate that the patient is cured or has immunity and is not infectious. If the fifth item is positive alone, it can indicate that the patient has been infected with hepatitis B virus, or the patient with hepatitis B virus is in early recovery. It is recommended that patients with positive hepatitis B core antibody should take into account their own situation and go to the hospital to improve the relevant examinations, so as to clarify their condition.