Taking anti-Helicobacter pylori medicine more difficult may be due to the stimulation of the gastric mucosa of the drug or the emergence of other adverse reactions. 1. Antibiotics such as metronidazole, clarithromycin, amoxicillin, etc., which have the effect of eradicating H. pylori, but also have the side effect of stimulating the gastric mucosa, and regurgitation and so on can occur after taking them. Therefore, it is recommended that patients take them after meals, or drink more water as appropriate to promote drug metabolism. 2. Eradication of Helicobacter pylori treatment is commonly used to omeprazole, lansoprazole and other proton pump inhibitors, some patients can appear nausea, vomiting, abdominal distension, abdominal pain, diarrhea and other gastrointestinal symptoms after taking the drug, but also can cause dizziness, headache and other discomforts, and even hives, itchy skin symptoms also appear. If the patient takes the medication and develops obvious uncomfortable symptoms, he/she needs to stop taking the medication immediately and go to the regular hospital for examination and change the medication under the doctor’s guidance.