High core antibody to hepatitis B virus suggests chronic hepatitis B virus infection, previous infection with the hepatitis B virus, or vaccination against the hepatitis B virus. Anti-HBc can be detected throughout the course of HBV infection. 1. Chronic Hepatitis B virus infection: may also be a carrier of Hepatitis B virus or an acute Hepatitis B virus infected person, usually the nuclear antibody IgM of Hepatitis B virus is positive, and accompanied by positive surface antigen, positive e antigen and positive e antibody of Hepatitis B virus. 2. Previously infected with hepatitis B virus: now the virus has been cleared or antibodies have been produced after vaccination against hepatitis B virus, which may be accompanied by positive e antibody or hepatitis B virus surface antibody, and generally do not need special treatment. High core antibody against hepatitis B virus can be further examined and diagnosed, and treatment can be carried out under doctor’s advice.