Blood in the urine of middle-aged women is related to abnormalities in the urinary and reproductive systems, and the main causes of these conditions include urinary stones, tumors in the urinary system, inflammation of the urinary tract, menstruation, and vaginal inflammation. 1. Urolithiasis: Urolithiasis stone scratches the wall of ureter, during which it will cause capillary rupture and cause hematuria. 2. Tumor of urinary system: Kidney cancer, renal pelvis cancer and bladder cancer will cause ulceration of the surrounding mucous membrane, which will cause capillary rupture and lead to hematuria. 3. Inflammation of urinary tract: Inflammation of urinary tract can cause damage to mucous membrane, resulting in capillary rupture and bleeding. 4. Menstruation: When menstruation occurs, menstrual blood is sometimes discharged along with urine, causing hematuria. 5. Vaginal inflammation: vaginal inflammation can cause mucosal damage and bleeding, which can cause hematuria when urine is discharged. Middle-aged women who have blood in the urine may also be caused by other factors, if the symptoms of blood in the urine have not improved and accompanied by a decline in health, you need to go to a regular hospital in time to observe, diagnose the specific situation in the clinician’s guidance to standardize the treatment, to avoid delays in the condition.