Lung adenocarcinoma in advanced stage can be treated with pain relieving drugs. In the late stage of lung adenocarcinoma, due to the gradual enlargement of cancer cells, it may cause invasion to pleura and bone, and patients may have the symptom of chest pain, and its symptom may gradually aggravate and persist for a long time. Patients with chest pain can be given pain relieving drugs and the pain relieving drugs can be adjusted in a stepwise incremental manner. Lung adenocarcinoma pain should be treated with painkillers from the first ladder, i.e. non-opioid drugs, such as diclofenac sodium, etc. Some patients can be given sedative drugs at the same time, which can increase the effect of pain relief. If the pain continues to aggravate, weak opioids such as codeine and tramadol can be given. For patients with particularly severe pain in the advanced stage of the disease, oral morphine is the mainstay, which can increase the pain-relieving effect and reduce the pain caused by lung cancer. Pain caused by bone metastasis of lung cancer can also be treated by radiotherapy. Radiotherapy has better efficacy in pain caused by bone metastasis. Specific medication should be taken under the guidance of doctor, do not use medication or increase the dosage arbitrarily.