Taking entecavir virus does not turn negative can be under the guidance of the doctor to consider continuing to take entecavir, switch to tenofovir or take a combination of drugs and other options. Entecavir is currently the first-line anti-hepatitis B virus drug, usually some people can turn negative after standardized entecavir antiviral treatment, but some people may not turn negative for a long time after taking the drug. It should be analyzed whether there are problems with the method of taking the medicine or the medicine is not standardized, such as frequent omission of taking the medicine or eating before or after taking the medicine. If the virus does not turn negative, it is possible that the medication has not been taken long enough, so you need to continue to take entecavir, or it is possible that you are not sensitive to this medication, so you can switch to tenofovir. It is also possible that the viral load in the body is too high, resulting in failure to convert, in which case a combination of drugs can be used. All of the above medication regimens should be formulated under the guidance of a doctor after examination, and should not be changed without authorization.