Pimples on men’s faces, often referred to as acne, can be treated with topical medications, oral medications, and physical therapy for relief. 1. Topical medication: For mild to moderate acne, retinoic acid cream can be used according to the doctor’s recommendation, which can improve the keratinization of the sebaceous gland ducts of the hair follicles. If necessary, it can be used in combination with antibiotic drugs such as erythromycin ointment and fusidic acid cream to prevent secondary bacterial infections of acne. 2. Oral medication: For moderate and severe acne, as it is related to Propionibacterium acnes infection, oral antibiotics, such as tetracycline, minocycline, erythromycin, roxithromycin and so on, can be chosen in conjunction with the doctor. For severe acne, glucocorticosteroids, such as hydrocortisone, mometasone furoate, etc., can be chosen if necessary. 3. Physical therapy: For patients with mild to moderate skin damage, red light and blue light irradiation can be used in combination to destroy Propionibacterium acnes through photodynamic effect and reduce local inflammatory response. It is recommended that men with acne on their faces should go to the dermatology department of a regular hospital and take targeted treatment under the guidance of a doctor, and not blindly use medication on their own.