Cough worse after taking medication may be due to diagnostic errors, exacerbation and symptoms caused by the normal course of the disease. 1. Diagnostic error: it is possible that the patient is reflux esophagitis caused by cough, if it is eaten aminoglutethimide and other cough and phlegm drugs to stop coughing is not effective, need to take omeprazole, moxapride and other drugs to treat the cough may only get better. 2. Exacerbation: If the patient’s cough is initially caused by the common cold, due to low resistance or improper care, it may be secondary to bacterial infection, causing cough aggravation, resulting in the original cough suppressant drugs have poor results. At this time, antibiotics such as amoxicillin, cefixime and other drugs need to be used to fight infection and relieve symptoms. 3. The normal course of the disease: pneumonia can have cough and other symptoms, such as treatment is effective, the fever and other symptoms can be improved, but with the improvement of the lesions in the lungs, may accelerate the sputum discharge, which can lead to increased coughing symptoms, this is the normal process of disease recovery. There are other reasons that can cause the cough to be more serious after taking medication, if the cough symptoms are more serious, it is recommended to go to the hospital in time to check and clarify the cause of the disease, so as not to delay the condition.