Vague pain and discomfort in the upper part of the stomach may be caused by chronic gastric disease, pancreatic disease, cardiovascular disease, etc. The most common causes are gastritis and gastric ulcer. 1. Chronic gastric disease: the most common cause of vague pain in the upper part of the stomach is gastritis and gastric ulcer, unclean or irregular diet, long-term alcohol consumption, spicy taste or long-term intake of drugs that stimulate the gastric mucosa, such as aspirin, diclofenac sodium, etc., can cause gastritis and gastric ulcer, resulting in vague pain in the upper part of the stomach, which needs to be clarified by perfect gastroscopy. 2. Pancreatic disease: because the location of the pancreas is located in the left upper abdomen, so some patients with vague pain in the upper stomach may be caused by pancreatic disease, if accompanied by back pain, we should consider the possibility of pancreatitis, need to improve the blood and urine amylase, blood, abdominal ultrasound and other tests to confirm the diagnosis. 3. Cardiovascular disease: some patients with coronary heart disease, angina pectoris or lower wall myocardial infarction, the onset of symptoms are not typical, may also be manifested in the upper part of the stomach pain discomfort, need to improve the electrocardiogram, myocardial enzymes, cardiac ultrasound and other tests to clarify. Upper stomach pain and discomfort may also be caused by other diseases, need to go to the hospital in time, under the guidance of a professional physician to clarify the cause of the disease, to avoid delaying the condition.