Treating H. pylori with only amoxicillin and no clarithromycin is not acceptable. Treatment of H. pylori can be done using triple or quadruple therapy. Both of these treatment options require the use of two antibiotics, so only using amoxicillin and not using clarithromycin is not acceptable, which will affect the efficacy of the drug, and can not achieve the effect of eradicating H. pylori, usually also need to take omeprazole, bismuth potassium citrate and so on. Amoxicillin has a strong bactericidal effect, can penetrate the cell membrane, is currently widely used penicillin. Taking amoxicillin may cause hives, rash, nausea, vomiting, diarrhea, anemia, insomnia and other adverse reactions; it is prohibited for those who are allergic to penicillin. Clarithromycin belongs to macrolide antibiotics. Taking Clarithromycin may cause nausea, heartburn sensation, abdominal pain, diarrhea, headache and other adverse reactions; lactating women, severe hepatic and renal insufficiency with caution; allergic to macrolides, pregnant women are prohibited. The above drugs should be used under the guidance of a professional physician. After Helicobacter pylori infection, it is recommended to consult a doctor in time, follow the doctor’s instructions to use the medication, do not stop the medication on your own, so as not to affect the efficacy of the treatment.