Syphilis can be judged to be cured after regular treatment and follow-up for 2~3 years according to regulations, with no recurrence of clinical symptoms or serologic recurrence, titer turning negative or serologic fixation. Syphilis is a chronic infectious disease caused by syphilis spirochete infection. Clinically, it is mainly transmitted through sexual contact, mother-to-child transmission and blood transmission. Due to the greater harm of the disease, once diagnosed, penicillin antibiotic treatment should be selected as early as possible in a timely manner. After the medication, the titer decreased by 4 times or more than 4 times than before the treatment is the effective treatment, and the titer turned to negative is the clinical cure, but still need to be regularly rechecked. However, regular follow-up is required. After 2 to 3 years of follow-up, the patient will be judged to be cured if there is no recurrence of clinical symptoms or serologic recurrence, and the titer has turned negative or the serum has been fixed. Syphilis should be treated as early as possible and in accordance with the doctor’s instructions. Early diagnosis, timely and standardized treatment, and adequate follow-up are important measures for the treatment of syphilis.