Symptoms of CDKL5 gene mutation are mainly early onset epilepsy, but patients can also experience neurological developmental delay, which can cause cognitive, motor, language, and visual dysfunction. CDKL5 is a cell cycle-like protein-dependent protein kinase 5 located on the X chromosome. Mutations in the gene that result in abnormal coding of the corresponding protein cause a series of neurological symptoms, such as epilepsy, growth retardation, hypotonia, autism, anorexia, scoliosis, etc., collectively referred to as CDKL5 syndrome. Because the gene is located on the X chromosome, the incidence of the disease is mainly in female children. There is no specific treatment, so the patient should follow the doctor’s instructions to prevent complications and aggravation of the disease.