Pemphigus requires systemic medication, and topical medications do not have a definitive therapeutic effect. It is recommended that patients systematically use glucocorticoids, immunosuppressants, or biologics as prescribed by a physician. 1. Glucocorticoid: It is the first-line drug in the treatment of pemphigus. This kind of drug has the effect of anti-inflammation, anti-allergy and immunosuppression, and the common ones are prednisone, methylprednisolone and so on. 2. Immunosuppressants: for moderate to severe patients, immunosuppressants can be used in combination, such as oral cyclosporine, cyclophosphamide and methotrexate, which can regulate the body’s immune system and reduce the dosage of glucocorticoids. 3. Biological agents: For patients with moderate to severe pemphigus, injection of biological agents such as rituximab can alleviate the condition under the guidance of the doctor. For patients suffering from pemphigus, it is recommended to go to regular hospitals, cooperate with doctors for standardized treatment, and use medication under the guidance of doctors, do not take medication without authorization.