Stage 2 syphilis rash includes syphilis rash and flat warts. The syphilis rash is generalized, while the flat warts are located mainly on the genitals and anus. Stage 2 syphilis results from untreated or incomplete treatment of stage 1 syphilis and usually appears 3 to 4 weeks after the noma has subsided, and may be preceded by symptoms such as low-grade fever, headache, and malaise. The most common cutaneous mucosal lesion of stage 2 syphilis is the syphilis rash, which is usually generalized, painless, and itchless, presenting as a rose-red, maroon, or copper-red rash, often generalized and symmetrically distributed. The syphilis rash that occurs on the palms of the hands and soles of the feet is specific, manifesting itself as a mung bean to soybean-sized, copper-red, infiltrative maculopapular rash or maculopapular rash, which is often ring-collared and flaky. And flat warts occur in the genitals, anus, groin area and other parts of the body, often manifested as flesh-colored or pink flat papules or plaques, the surface of the vesicular moist, highly contagious. Stage II syphilis rash can subside on its own in 2~3 months if left untreated, and in severe cases, it can develop into the third stage of syphilis. If actively treated, the prognosis is relatively good. It is recommended that patients with syphilis go to regular hospitals in a timely manner, standardized treatment under the guidance of the doctor, and sexual partners are recommended to be treated at the same time.