The hazards of Pyrexone Cream, also known as Trimethoprim Econazole Cream, are also known as adverse reactions, including: localized allergies, and adverse reactions to long-term use. Trimethoprim Econazole Cream is a compound preparation, mainly containing antifungal drug components as well as glucocorticoid drug components, adverse reactions are: 1. Local allergy: causing burning sensation, itching, pinprick sensation and other symptoms of the skin at the site of use. 2. Adverse effects of long-term use: long-term use of glucocorticoid-containing drugs may cause skin atrophy, hyperpigmentation, capillary dilatation, and secondary infections and other complications. Drugs need to be used under the guidance of a professional doctor to avoid abusing the drugs themselves.