Non-gonococcal urethritis can take antibiotics according to the bacterial culture and drug sensitivity test, before the results are not yet out can also be empirically applied broad-spectrum antibiotics, including tetracyclines, quinolones, macrolides. 1. Tetracyclines: including doxycycline, minocycline and so on, belong to the broad-spectrum antibiotics, through the inhibition of bacterial protein synthesis to play a role. However, the application may cause nausea, vomiting and other adverse reactions. 2. Quinolones: such as ofloxacin, levofloxacin, ciprofloxacin and other drugs, also belongs to the broad-spectrum antibiotics, nongonococcal urethritis in the application of this type of antibiotics. The main adverse reactions include nausea, vomiting and other gastrointestinal adverse reactions. 3. macrolides: non-gonococcal urethritis can also apply macrolide antibiotics, including azithromycin, erythromycin and so on. Patients should take the drugs under the guidance of the doctor, according to the patient’s condition is different, the drugs used are different.