Gastric sinus mucosal lesion is a condition in which the mucosal surface of the gastric sinus becomes incomplete after irritation and bleeding, erosion, and ulceration occur. 1. The gastric sinus is a portion of tissue that exists between the body of the stomach and the pylorus. Gastric sinus mucosal lesion refers to pathological changes in the mucosa of the gastric sinus under the stimulation of viruses, bacteria or certain drugs, such as the appearance of bulging, erosion, bleeding and ulceration of the mucosa, and the scope of the lesion is confined to the mucosal layer. Patients will have symptoms such as stomach pain, nausea, vomiting or blood in stool. 2. After the appearance of gastric sinus mucosal lesions, the patient should firstly find out the cause of the disease and stop the damage of the predisposing factors; secondly, he should go to the hospital for gastroscopy to clarify the degree of development of the disease and the nature of the lesion; lastly, he should standardize the treatment under the guidance of the doctor.