The presence of urinary tract infections can be treated with levofloxacin, but for complicated or recurrent urinary tract infections, the application of antimicrobial agents should be selected based on the results of urine culture. Levofloxacin is a quinolone drug for mild and severe infections caused by sensitive bacteria. For example, respiratory system infections, including acute exacerbation of chronic bronchitis and community-acquired pneumonia; urinary system infections, such as acute pyelonephritis and urinary tract infections; reproductive system infections; skin and soft tissue infections and other infections. Its antibacterial effect is strong, effective against gram-negative bacteria such as Escherichia coli, Klebsiella spp, Proteus, Haemophilus influenzae and other gram-positive bacteria such as Staphylococcus aureus, Streptococcus pneumoniae, and others. Bacteria that cause urinary tract infections are commonly Escherichia coli, Klebsiella, Staphylococcus aureus, and so on. Therefore, Levofloxacin can be used to treat urinary tract infections caused by bacteria. Levofloxacin can cause gastrointestinal reactions, such as diarrhea, nausea, vomiting, etc.; central nervous system reactions such as dizziness, headache, drowsiness, etc.; allergic reactions and other adverse reactions. Patients allergic to levofloxacin and fluoroquinolones are prohibited. When applying, attention should be paid to adjusting the dosage with reference to the results of drug sensitivity, while those with reduced hepatic and renal functions need to adjust the dosage according to the situation. Patients with urinary tract infections should go to the hospital in a timely manner, under the guidance of the physician, complete the relevant examinations, follow the doctor’s instructions to use medication, avoid self-medication.