Immunoglobulin positivity is most commonly seen in autoimmune disorders, which suggests an infection, such as autoimmune disorders (systemic lupus, rheumatoid arthritis, etc.), infectious diseases, and blood disorders. Immunoglobulins are categorized into five major groups, namely IgG, IgA, IgM, IgD and IgE, depending on their functions and physicochemical properties. In different stages of diseases and infections, the type and content of immunoglobulins vary. 1. Autoimmune diseases: Immunoglobulin is positive in a variety of autoimmune diseases, such as systemic lupus, rheumatoid arthritis, ankylosing spondylitis, desiccation syndrome, etc., which are in the active stage of the disease, and the value of immunoglobulin is often increased. 2. Infectious diseases: immunoglobulin positivity may also be associated with chronic infections such as active tuberculosis and bacterial infections. 3. Hematologic diseases: Hematologic diseases such as multiple myeloma may present with an exponential increase in a certain type of immunoglobulin. It is advisable to consult a doctor to identify the cause of the disease and to treat it with appropriate therapy or treatment.