Toe seam peeling with blisters is commonly seen in tinea pedis, which needs to be treated with antifungal drugs. Tinea pedis is a fungal infection of the foot caused by dermatophytes, which can be transmitted by direct or indirect contact, and its symptoms are localized skin cracking, scaling, peeling, and blisters on the toe seams. It can be treated by applying creams such as miconazole nitrate cream and econazole nitrate cream under the guidance of a doctor. If the lesions are generalized and involve the toenails or the effect of external drugs is not good, oral antifungal drugs such as itraconazole, terbinafine and other treatments can be given. Patients should pay attention to personal hygiene in their daily life, and do not share shoes, socks, slippers and daily necessities with others. Specifically need to go to the hospital for consultation, clear diagnosis and follow the doctor’s prescription medication.