Captopril should not be used in combination with Timosartan because both drugs act on the renin-angiotensin-aldosterone system and are not recommended for use in combination. It is recommended to consult a healthcare professional and use the medication as prescribed by your doctor. 1. Captopril is an angiotensin-converting enzyme inhibitor antihypertensive drug, which can reduce peripheral vascular resistance and reduce sodium retention by inhibiting aldosterone secretion, as well as increase cardiac output and exercise tolerance time. It is suitable for heart failure and hypertension. Adverse reactions mainly include skin rash, palpitation, cough, etc.. 2. Timosartan is an angiotensin II receptor antagonist antihypertensive drug, which can cause vasodilation, and also inhibit cardiac excitation and renal reabsorption of sodium, aldosterone synthesis and release, etc., and has the effect of lowering blood pressure and cardiovascular risk. Adverse effects mainly include headache, fatigue, and allergy. Concomitant use of telmisartan with captopril is not recommended. However, if coughing occurs after taking oral captopril, consider changing to timosartan. Those who need to take captopril or timosartan are advised to strictly follow the doctor’s instructions and not to self-medicate.