Failure to pass urine may usually be due to urinary retention, which may be caused by quetiapine, but is less common. Urinary retention requires prompt medical attention. Quetiapine is an antipsychotic medication that is used in the treatment of schizophrenia and other disorders. There is a possibility of urinary retention with the use of this medication, which may be related to abnormal bladder or urethral neuromuscular function caused by the medication. In addition to this, adverse reactions such as dry mouth, constipation, blurred vision, and elevated blood lipids may occur with the use of this medication. In case of adverse reactions such as urinary retention, it is recommended to visit a hospital promptly, stop the drug if necessary, and leave a urinary catheter in place. It should be noted that the drug is prohibited for minors under 18 years of age, drug allergy. Caution is recommended for women during pregnancy and the elderly. Nursing women are advised to stop breastfeeding while using the drug. Quetiapine needs to be used under the supervision of a clinician.