Generalized fever, weakness and soreness of the limbs may be caused by infectious diseases, connective tissue disease, autonomic dysfunction, etc. Targeted treatment is needed after identifying the cause. If you need to use drugs, please under the guidance of a physician, do not self-medication, so as not to delay the course of the disease. 1. Infectious diseases When you suffer from infectious diseases such as pneumonia and colds, the pathogens will cause the hypothalamus thermoregulation point to rise, so it leads to generalized fever. Muscles undergo anaerobic respiration to produce lactic acid, etc., all of which can lead to weakness and soreness in the limbs. Bacterial infections can be applied with cefuroxime, moxifloxacin, azithromycin, etc. Viral infections can apply ribavirin, tenofovir, etc. 2. Connective tissue disease It is due to the disorder of autoimmune system, which causes the inflammatory reaction of various tissues and organs, thus the symptoms will appear. Non-steroidal anti-inflammatory drugs such as celecoxib and indomethacin, as well as glucocorticoid drugs such as prednisone and dexamethasone, and immunosuppressive drugs such as methotrexate and cyclophosphamide can be used for treatment. 3. Autonomic Nerve Dysfunction Due to the abnormal function of sympathetic and parasympathetic nerves (vagus nerve), it leads to generalized fever, weakness and pain in limbs. This can be treated with medications such as glutamine, methylcobalamin, and vitamin B1. In addition to the above, there are other conditions that may lead to generalized fever, limb weakness and pain, it is recommended to go to the hospital for examination, and follow the doctor’s instructions for targeted treatment, do not take care of yourself, so as not to delay the course of the disease.