Acne on the face of a 15-year-old boy may be related to abnormal keratinization of the opening of the sebaceous glands of the hair follicles, Propionibacterium acnes infection, and so on, and need to treat the cause with medication and physical therapy. 1. For the abnormal keratinization of follicular sebaceous glands, you can use topical retinoic acid cream to dissolve the keratin, which can help to alleviate the situation of acne. At the same time, you should pay attention to avoid staying up late and eat less spicy and stimulating food, which can reduce the secretion of oil. 2. For the Propionibacterium acnes infection, you can follow the doctor’s instructions to use azelaic acid, fusidic acid and other antibacterial ointment, oral minocycline and other antibacterial drugs; blue light irradiation and other physical therapy can play a role in killing Propionibacterium acnes and anti-inflammatory effect. It is recommended that the 15-year-old boy with acne on his face go to a regular hospital in time to clarify the cause of the disease and standardize the treatment under the guidance of the doctor.