Cranioplasty has undergone a long developmental journey and the outcome of the repair is influenced by many factors, among which material is the most important. A material that performs well in all aspects not only increases the success rate of the procedure, but also greatly reduces the chance of postoperative complications. The materials for skull repair have gone through iterations, and the rise of each new material and the withdrawal of the old one is a great innovation in technology and a great progress in neurosurgery. Is titanium mesh good for skull repair? Titanium mesh is one of the most used materials in the field of neurosurgery to repair the skull, and many patients with skull defects choose to use titanium mesh to restore the skull to integrity. The duration of use of titanium mesh is determined by the patient’s post-operative recovery. Some patients with titanium mesh repair may not experience discomfort after surgery and the mesh is not exposed. In this case, it can be used essentially for life. In other cases, the cranial area repaired with a titanium mesh may become infected or deformed by external forces, resulting in exposure, months or years after surgery. In such cases, the patient may be faced with the problem of replacing the material, and it is recommended that the patient go to the hospital for symptomatic treatment in the first instance, and then further consider the issue of material replacement at the discretion of the surgeon. Currently, the advanced and ideal material for skull repair is polyetheretherketone PEEK. This advanced material has been used in neurosurgery for a long time and has achieved ideal results in clinical practice.PEEK material is able to replicate the defective part of the human skull and reconstruct the design based on CT data through advanced 3D printing technology to match the defective area and meet the high demand of patients for perfect restoration of the defective area.The good histocompatibility of PEEK material, its stable chemical properties, the modulus of elasticity and cortical bone, even in the event of a collision, will not depress or deform, playing a vital role in cranial bone repair surgery. Of course peek cranioplasty is an advanced and mature technology that integrates advanced peek material implants with the concept of aesthetic plastic surgery, which can achieve lifelong use through a single repair, with more outstanding results in terms of aesthetic appearance.