Sleeping at night calf muscle soreness, may be fatigue, lower limb ischemic disease, restless legs syndrome, but also may be the lack of trace elements, electrolytes and other reasons. 1. Exhaustion: Lower limb fatigue caused by too much exercise during the daytime, over exertion, and a long-term posture can lead to calf muscle soreness at night. 2. Lower limb ischemic disease: for example, lower limb atherosclerosis, lower limb venous valvular insufficiency, lower limb arterial occlusive vasculitis and varicose veins and other diseases, will lead to calf muscle pain at night. 3. Restless legs syndrome: a central nervous system disease, manifested as bilateral calf gastrocnemius muscle pain, soreness, burning, itching, etc., can also lead to calf muscle soreness at night. 4. lack of trace elements, electrolytes, etc.: for example, calcium deficiency, potassium deficiency and other reasons, may also lead to sleep at night calf muscle soreness. There may be other reasons for sore calf muscles at night, so you need to go to the hospital first to check the cause.