There are more reasons for the soreness inside the knee joint, the more common are knee trauma, osteoarthritis, gouty arthritis, rheumatoid arthritis, synovitis, etc. Different causes of different treatment modalities, commonly used general treatment (reduce walking, etc.), physical therapy (hot compresses, etc.), drug therapy (ibuprofen, etc.) and surgical treatment. 1. Knee trauma: need to reduce activities, give cold compresses in the acute stage within 72h, give hot compresses in the relief stage after 72h, give ibuprofen and other painkillers for severe pain, and give arthroscopic meniscal repair for serious meniscus injuries. 2. Osteoarthritis: reduce weight bearing and strenuous exercise, etc., severe pain can be given to diclofenac sodium and other pain relieving drugs, but also intra-articular injection of sodium vitrate and other drugs, for the knee joint damage can be given to the serious surgical treatment, such as knee arthroplasty and so on. 3. Gouty arthritis: Colchicine and other drugs can be given in the acute stage, and Benzbromarone and other drugs to reduce uric acid can be given in the remission stage. 4. Rheumatoid arthritis: mostly caused by streptococcal infection, need to give antibacterial drugs such as amoxicillin for treatment, can also give prednisone and other glucocorticoid drugs. 5. synovitis: ibuprofen and other non-steroidal anti-inflammatory drugs can be given to the treatment, but also intra-articular injection of trimethoprim and other glucocorticosteroid drugs, serious arthroscopy can also be given to the sliding membrane lesions such as tissue removal surgery. It is recommended to go to the hospital in a timely manner to improve the examination, to clarify the cause of the disease, the drugs need to be used under the guidance of a professional physician, so as not to delay the condition.