Oxaliplatin has little effect on the heart, some patients may have arrhythmia after chemotherapy, but it may lead to other adverse reactions such as neurotoxicity and gastrointestinal reactions. Oxaliplatin is an anti-tumor chemotherapeutic drug, which is more effective in the treatment of metastatic colorectal cancer and colon cancer after complete resection, and the drug may cause some effects on the heart, leading to arrhythmia in patients, but most of the effects on the heart will be gradually recovered on their own after stopping the drug. Oxaliplatin may also cause some other adverse reactions, among which the more common ones are dullness of sensation, abnormal sensation, nausea and vomiting, diarrhea and other symptoms. It is contraindicated for those who are allergic to the components of the drug, nursing women, and should not be mixed with alkaline drugs or solutions when using the drug. The drug should be used under the guidance of a doctor. And pay attention to observation during the use of the drug, if the adverse reaction is obvious to consult a doctor in time, if necessary, need to stop chemotherapy.