Silymarin should not be taken with antituberculous, chemotherapeutic, or nonsteroidal anti-inflammatory drugs. 1. Anti-tuberculosis class: Silymarin is a kind of drug for the treatment of toxicity, acute and chronic hepatitis, immune liver injury, alcoholic hepatitis and other diseases. Since anti-tuberculosis drugs, such as isoniazid tablets, rifampicin capsules, etc., can lead to certain damage to the patient’s liver, thus affecting the efficacy of silymarin, it is usually not recommended to take silymarin with anti-tuberculosis drugs. 2. Chemotherapy: As most chemotherapy drugs kill cancer cells, the side effects of chemotherapy may also cause damage to the liver function of patients and aggravate the condition of abnormal liver function, while most drugs are metabolized through the liver, which will also aggravate the burden on the liver and affect the treatment of abnormal liver function, so it is not recommended to take them together. 3. Non-steroidal anti-inflammatory drugs: such as aspirin tablets, acetaminophen tablets, ibuprofen tablets, etc., may cause varying degrees of liver damage, resulting in increased bilirubin, which is not conducive to the recovery of liver function, so it is not recommended to take together. Patients with abnormal liver function should go to the hospital in time for relevant examinations to clarify the cause of the disease, and then choose the appropriate medication for treatment under the guidance of the doctor.