Whether or not you need to take medication with long-acting insulin needs to be determined on a patient-by-patient basis. For example, patients who can control their blood glucose well only with long-acting insulin generally do not need to take medication, while patients with type 2 diabetes who have poor blood glucose control only with long-acting insulin need to consider taking a combination of medication. 1. For diabetic patients who can control their blood glucose within a reasonable range only by injecting long-acting insulin with dietary control and physical exercise, they do not need to take medication. Meanwhile, insulin injection therapy is recommended for patients with type 1 diabetes. 2. For patients with type 2 diabetes who cannot control their blood glucose well by only taking long-acting insulin, they need to take oral hypoglycemic drugs under the guidance of a doctor to control their blood glucose within a reasonable range, which helps to avoid the occurrence of diabetes-related complications. Patients who need to use long-acting insulin or a combination of oral hypoglycemic agents should be treated under the guidance of a doctor.