Clinical advice to take three months sertraline ineffective can be considered to change the drug, the patient has only taken 50 days, can still continue to take. Sertraline can block the reuptake of 5-hydroxytryptamine, increase the synaptic gap 5-hydroxytryptamine concentration, thus enhancing the central 5-hydroxytryptaminergic neurological function, play an antidepressant effect, this product can also be used to treat obsessive-compulsive disorder. Sertraline after the use of common neurological abnormalities, such as headache and dizziness, tremor drowsiness, increased muscle tone, etc.; gastrointestinal abnormalities, such as nausea and vomiting, abdominal pain and constipation, dyspepsia, dry mouth diarrhea, etc.; it can also lead to sexual dysfunction, chest pain, malaise and other adverse reactions. Note that it is prohibited for those who are allergic to this product. Combination with monoamine oxidase inhibitors such as moclobemide and pimozide is prohibited. Patients must use the drug under the guidance of a professional physician, and strictly comply with the medical advice, do not arbitrarily stop or change the drug.