Whether urine protein +- is normal or not depends mainly on the cause of the weak positive urine protein. If it is caused by physiological factors such as fever, strenuous exercise, this situation is normal and does not require special treatment; if it is caused by pathologic factors such as nephritis, urinary tract infections and other diseases, this situation is not normal, and need to consult a doctor. 1. Physiological factors: such as strenuous exercise, fever, low-temperature stimulation, sympathetic nerve excitation and other factors, can lead to abnormal urinary protein, urinalysis urinary protein +- situation. The patient’s kidneys have no organic lesions, no special treatment is needed, and the urine protein can usually turn negative by itself after rest. 2. Pathologic factors: (1) nephritis: patients suffering from nephritis, usually the glomerular filtration is impaired, and the phenomenon of urine protein +- in urine test can occur. (2) urinary tract infection: urinary tract infection is usually caused by bacterial infection, will stimulate the body’s urinary system mucosa is seriously affected, producing inflammatory protein secretion, can appear urine test urine protein +-. Urine protein +- may also have other reasons, if the patient found urine protein positive, it is recommended to go to the regular hospital in a timely manner, improve the examination to clarify the cause of the disease, under the guidance of the doctor to targeted treatment or treatment.