Vulvar sclerosis leukoplakia can be actively treated with glucocorticoid preparations such as tretinoin cream, immunosuppressants such as tacrolimus ointment, moisturizing and emollient creams such as vitamin E cream, and antibiotic ointments such as erythromycin cream, as prescribed by the doctor. Vulvar sclerosing leukoplakia refers to a lesion of limited or diffuse hypopigmentation of the vulvar skin of women, which is often characterized by localized itching, dry skin, and thickening of the skin. 1. Glucocorticoid preparation: glucocorticoid ointment such as tretinoin cream can be used to regulate the local immunity and improve the itching symptoms as prescribed by the doctor. 2. Immunosuppressants: Tacrolimus ointment, pimecrolimus cream and other immunosuppressants can be used to stimulate local immune factors and inhibit local lesions. 3. Moisturizing and emollient cream: Vitamin E cream can be used for local application to improve the dryness of the vulva. 4. Antibiotic ointment: If the local skin is broken, red and swollen and combined with bacterial infection, it can be combined with erythromycin ointment or mupirocin ointment and other antibiotic preparations to fight infection. All of the above drugs should be used according to the doctor’s prescription. For patients with vulvar sclerosis leukoplakia, it is recommended to go to the gynecology and dermatology departments of regular hospitals in a timely manner, and choose the appropriate treatment under the guidance of the doctor, and do not use medication on your own.