Hand bladder pain and swelling may be caused by excessive exercise, upper extremity deep vein thrombosis, rheumatoid arthritis and other diseases. 1. Excessive exercise: too much force on the hand and bladder, too much exertion, can lead to hand and bladder muscles, ligaments, fascia and other soft tissue injuries, inflammation, manifested as localized swelling and pain. 2. Upper extremity deep vein thrombosis: endothelial damage or coagulation abnormalities, deep vein thrombosis in the hands and bladder area will lead to venous blood reflux obstruction, the accumulation of venous blood in the stasis of the formation of swelling, stimulation of the peripheral nerves, resulting in pain, skin bruising. 3. Rheumatoid arthritis: usually associated with streptococcal infection, mainly involving large joints such as knees, elbows, ankles, shoulders, etc. When the elbow joints appear red, swollen, hot and painful, there may be swelling and pain in the hands and bladder. The pain and swelling of the hands and bladder may be caused by other reasons, it is recommended to go to the hospital in a timely manner, improve the examination to clarify the cause of the disease, and then give targeted treatment or treatment.