Diffuse liver lesions, if caused by hepatitis B, can control the symptoms through medication; fatty liver, can be cured by quitting alcohol, losing weight, treating diabetes, etc.; if it is cirrhosis, it may need liver transplantation. 1. Hepatitis B is a common cause of diffuse liver lesions. If it is in the active stage, it can be treated with drugs such as entecavir, lamivudine and interferon, which can control the disease progression and prevent it from developing into cirrhosis. 2. Fatty liver, imaging tests will find diffuse changes, pay attention to alcohol cessation, obese people control diet, exercise to lose weight, diabetic patients control blood sugar, etc., generally can be cured. 3. Cirrhosis, early by actively treating the cause of the disease, can delay the condition, advanced cirrhosis can not be cured, need to do liver transplantation. Discovery of diffuse liver lesions, timely search for the cause, regular treatment.