Hospitalized bilirubin has been elevated with hemolysis, hepatocellular damage, cholestasis and other reasons, according to the cause of the need to comply with the doctor’s instructions for hormone shock therapy, alkalinization of the urine, hepatoprotection, antiviral and surgical treatment, as follows. 1. Hemolysis: such as marine anemia, hereditary spherocytosis, autoimmune hemolysis and other diseases, due to the destruction of a large number of red blood cells, and bilirubin elevation, need to comply with the medical advice according to the cause of glucocorticoids, immunosuppressants and other treatments, and plasma replacement or surgical treatment if necessary. 2. Hepatocellular damage: such as viral hepatitis, cirrhosis and other diseases, due to severe damage to hepatocytes, resulting in decreased bilirubin uptake, bilirubin binding function of the liver and bilirubin elevation, need to comply with the medical advice to be hepatoprotective, promote hepatocyte regeneration, antiviral and other treatments for the cause of the disease. 3. Cholestasis: bile secretion dysfunction caused by intrahepatic bile duct stones, drug-induced cholestasis, choledocholithiasis, etc., resulting in elevated bilirubin, which needs to be treated by discontinuing appropriate drugs and surgery according to the cause of the disease. There are many reasons for elevated bilirubin, and the constant elevation of bilirubin after hospitalization may be the stage of disease progression, so patients should follow the doctor’s instructions for targeted treatment.