Hepatitis B generally refers to chronic hepatitis B. Although gibberellic acid has medicinal value, hepatitis B patients need to be cautious about long-term use. Hepatitis B is a viral hepatitis caused by hepatitis B virus infection, should be based on the condition to take a comprehensive, individualized treatment program. It includes rational diet, anti-hepatitis B virus, anti-fibrosis and surgical treatment if necessary. In addition, in hepatitis B treatment, appropriate traditional Chinese medicine is necessary, and Chinese herbs play a beneficial role in liver protection, yellowing reduction, and antifibrotic treatment. Gynostemma contains saponins, flavonoids and a variety of trace elements, which have the effect of clearing away heat and detoxification (removing heat and toxicity from the body), replenishing qi and generating fluids, and assisting in the treatment of high blood pressure, hyperlipidemia, and liver protection. However, gynostemma is cold in nature, and long-term use of gynostemma is prone to stomach pain, diarrhea, dizziness, tinnitus, nausea and other reactions. The advantages and disadvantages of gynostemma for the treatment of hepatitis B need to listen to the doctor’s opinion after diagnosis and treatment. Long-term use of gibberellic acid may be counterproductive.