Pyloric ulcer 5cm x 3cm is considered a relatively large ulcer, if there is no malignant transformation, bleeding, perforation, etc., it is not very serious; if complicated by the above complications, it is more serious. Generally, ulcers larger than 2cm can be called giant ulcers, so pyloric ulcer 5cm×3cm is considered to be a relatively large ulcer, which is very easy to induce gastric cancer, perforation, bleeding and other complications; if the above complications do not occur is not considered to be serious, at this time, you can comply with the doctor’s instructions by taking acid-suppressing drugs such as omeprazole, and gastric mucous membrane protective agents such as aluminum sulfate and other drug therapy. If gastric cancer, perforation, bleeding and other complications occur or treatment is ineffective, then it is more serious and surgical treatment should be considered. Patients with pyloric ulcer of 5cm×3cm should actively cooperate with doctors and maintain a healthy diet. Medications should be used under the guidance of a doctor.