Penile tenderness after a period of erectile softness, usually considered with urethritis, prostatitis, seminal vesiculitis and other diseases caused by the need to choose the appropriate method of treatment according to the different causes, including the use of amoxicillin capsules, tamsulosin, levofloxacin tablets and other drugs treatment. 1. Urethritis: If there is urethritis, it can cause symptoms such as hidden pain in the penis, vaginitis may also occur frequent urination, painful urination, urinary urgency, hematuria and other symptoms, can be treated with amoxicillin capsule medication under the guidance of a doctor. 2. Prostatitis: It may be due to inflammation of the prostate gland stimulating the penis area, which can also cause hidden pain in the penis. Prostatitis may also cause pain in the perineum and abnormal urination, which can be treated with tamsulosin and levofloxacin tablets as prescribed by the doctor. 3. Spermatitis: It is usually due to the inflammation of the seminal vesicles, which in turn causes the phenomenon of hidden pain in the penis after a period of time when the erection is soft. Vesiculitis usually appear blood sperm, pain and other symptoms, can follow the doctor’s instructions to use amoxicillin capsules, levofloxacin tablets and other drugs to treat. All the above drugs need to pay attention to the side effects and adverse reactions of the drugs, please use the above drugs under the guidance of a doctor. It is recommended to consult the doctor in the hospital in time to find out the cause and actively treat it. In daily life, you should pay attention to rest, appropriate exercise, avoid overwork, improve immunity, and you should avoid excessive sexual life.