Brucellosis, i.e. brucellosis, can turn negative in about 6~9 weeks of treatment, and the exact time is also related to the stage of brucellosis and the living environment. 1. Acute brucellosis: standardized treatment can turn negative in about 6 months, mainly using antibacterial drug treatment. For adults and children over eight years old, doxycycline combined with rifampicin is preferred, or doxycycline combined with streptomycin. For children under the age of eight or pregnant women, rifampicin combined with cotrimoxazole is used for treatment, and all drugs must be used under the guidance of a professional doctor. 2. Chronic brucellosis: the course of the disease is longer, about nine months to turn negative. The drug treatment is the same as acute brucellosis, and several courses of treatment need to be repeated. In addition, a small number of injections of Brucella antigen can also be used to avoid severe tissue damage, desensitization therapy. 3. Living environment: Brucellosis is mainly transmitted through contact with animals with Brucella, such as sheep, cattle, pigs, etc. Therefore, if you live for a long time in pastoral areas, semi-pastoral and semi-agricultural areas, etc., you will be in the environment of germs all the time, and you may be positive for a long time. Brucellosis patients need to pay attention to rest, strengthen nutrition, improve their immunity, which is conducive to the recovery of the disease. Please do not self-medicate, it is recommended to go to the hospital, under the guidance of the doctor’s diagnosis and treatment.