Stem cell transplantation with severe bowel rejection can be treated with drugs such as methylprednisolone combined with cyclosporine A. Stem cell transplantation is currently one of the effective means of treatment for various malignant hematologic diseases, but various rejection reactions may occur after stem cell transplantation. Intestinal rejection reaction is mainly manifested as nausea and vomiting as well as watery stools, and in severe cases, it may even be accompanied by detached intestinal mucosal epithelium. Methylprednisolone combined with cyclosporine A and other drugs are mainly used for treatment. Methylprednisolone belongs to glucocorticoid, when applying it, it should be careful not to increase or decrease the dosage or stop the drug arbitrarily so as not to cause drug withdrawal reaction. Stem cell transplantation of intestinal rejection is serious, it is recommended to go to the hospital in a timely manner, early regular treatment. All the above medications should be used under the guidance of a doctor, avoid self-medication.