Breast cancer ER negative PR negative her2 is 3+ belongs to the relatively more aggressive type of breast cancer, this type of breast cancer is more likely to recur after treatment. However, it needs to be combined with the patient’s clinical stage, age and other factors to comprehensively determine whether it is serious. Breast cancer ER negative PR negative her2 is 3+ refers to estrogen, progesterone receptor is negative, oncogene epidermal growth factor receptor 2 overexpression of breast cancer, this type of breast cancer is easy to recur after surgery, the need for postoperative adjuvant chemotherapy + targeted therapy to reduce the probability of recurrence of the tumor, such as doxorubicin, trastuzumab and so on. Therefore, breast cancer ER negative PR negative her2 is 3+ patients should go to the hospital in time, according to the doctor’s guidance and recommendations for regular treatment.